Diclozone-plus

Diclozone( Diclofenac) is used to treat pain, inflammatory disorders, and dysmenorrhea
Inflammatory disorders may include musculoskeletal complaints, especially arthritisrheumatoid arthritis,
polymyositisdermatomyositisosteoarthritis, dental pain, TMJ painspondylarthritisankylosing spondylitisgout attacks. 
Category:

Description

Composition:  
Diclozone: Each tablet contains…….. Diclofenac Potassium BP 50mg
Diclozone-Plus: Each tablet contains ..Diclofenac Potassium BP 50mg and Paracetamol BP 500mg. 
 
Pharmacological Category: Diclofenac potassium belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). 
 
Mechanism of action: The exact mechanism of action is not entirely known, but the primary mechanism
responsible for its anti-inflammatoryantipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). 
 
Indications:  Diclozone( Diclofenac) is used to treat pain, inflammatory disorders, and dysmenorrhea
Inflammatory disorders may include musculoskeletal complaints, especially arthritisrheumatoid arthritis,
polymyositisdermatomyositisosteoarthritis, dental pain, TMJ painspondylarthritisankylosing spondylitisgout attacks. 
 
Dosing: After observing the response to initial therapy with Diclozone (diclofenac potassium immediate-release tablets), the dose and frequency should be adjusted to suit an individual patient’s needs. For the treatment of pain or primary dysmenorrhea the recommended dosage is 50 mg t.i.d. With experience, physicians may find that in some patients an initial dose of 100 mg of Diclozone (diclofenac potassium immediate-release tablets), followed by 50-mg doses, will provide better relief. 
For the relief of osteoarthritis the recommended dosage is 100-150 mg/day in divided doses, 50 mg b.i.d. or t.i.d. For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided 
doses, 50 mg t.i.d. or q.i.d. 
Side effects: Gastrointestinal experiences including abdominal pain, constipation, diarrhoea, dyspepsiaflatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting. Abnormal renal function, anaemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus,
rashes and tinnitus.  
Contraindication and Warnings: Diclozone (diclofenac potassium) is contraindicated in patients with known hypersensitivity to diclofenac. Diclofenac potassium should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic like reactions to NSAIDs have been reported in such patients. 
Diclofenac potassium is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. 
Identification: Diclozone: Brown biconvex tablet in 1×10 blister. Diclozone-plus: A white oblong tablet with a break line on one side in 1×10 blister. Diclozone is a prescription-only medicine (POM). 
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